The roles of factor Va and protein S in formation of the activated protein C/protein S/factor Va inactivation complex
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چکیده
منابع مشابه
Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S.
To test whether neutral glycosphingolipids can serve as anticoagulant cofactors, the effects of incorporation of neutral glycosphingolipids into phospholipid vesicles on anticoagulant and procoagulant reactions were studied. Glucosylceramide (GlcCer), lactosylceramide (LacCer), and globotriaosylceramide (Gb(3)Cer) in vesicles containing phosphatidylserine (PS) and phosphatidylcholine (PC) dose ...
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Cultured bovine aortic endothelial cells promote activated protein C-protein S-mediated inactivation of factor Va.
Previous studies have demonstrated that protein S is required for optimal activated protein C-mediated inactivation of Factor Va on the surface of either the platelet or phospholipid vesicles. In this report we demonstrate assembly of the activated protein C-protein S complex on the surface of cultured bovine aortic endothelial cells. Endothelial cell surface acceleration of Factor Va inactivat...
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Protein S expresses cofactor activity for activated protein C (APC) by enhancing the APC-catalyzed proteolysis at R306 in factor Va. It is generally accepted that only free protein S is active and that complex formation with C4b-binding protein (C4BP) inhibits the APC-cofactor activity of protein S. However, the present study shows that protein S-C4BP expresses APC-cofactor activity and stimula...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2019
ISSN: 1538-7933,1538-7836
DOI: 10.1111/jth.14594